RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-208a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
Animal model of RV failure; Cardiomyocytes isolation and culture etc.
Target
Med13
Pathway
MED13/NCOR1-MEF2 AXIS signaling pathway
PubMed ID
Title
A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension
Year
2015
Function
"Mef2c expression was sharply increased in compensating phase of RVH tissues but was lost in decompensation phase of RVH. Myocardium-specific miR-208 was progressively downregulated as RV failure progressed. MiR-208 inhibition, as well as tumor necrosis factor-a, activates the MED13/NCoR1 axis, which in turn promotes Mef2 inhibition, closing a self-limiting feedback loop, driving the transition from compensating phase of RVH toward decompensation phase of RVH. In our model, serum tumor necrosis factor-a levels progressively increased with time while serum miR-208 levels decreased, mirroring its levels in RV myocardium."